Recombinant MVP anticorps

N° du produit ABIN6941288

Cet anticorps Lapin Monoclonal détecte spécifiquement MVP dans IHC et StM. Il présente une réactivité envers Humain.

Aperçu rapide pour Recombinant MVP anticorps (ABIN6941288)

Antigène: MVP (Major Vault Protein (MVP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MVP est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: VP2897R

Détail du produit anti-MVP anticorps

Specificité: Recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70 % of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human MVP protein

Isotype: IgG

Information d'application

Indications d'application:

Positive Control: MCF-7/HeLa, breast tumors.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur MVP

Antigène: MVP (Major Vault Protein (MVP))

Autre désignation: MVP

Poids moléculaire: 104-110kDa

ID gène: 9961

UniProt: Q14764